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LncRNA ELF3-AS1 is involved in the regulation of oral squamous cell carcinoma cell proliferation by reprogramming glucose metabolism

OncoTargets and Therapy Aug 28, 2019

Chu H, Li Z, Gan Z, et al. - In order to determine the influence ELF3-AS1 has in oral squamous cell carcinoma (OSCC), researchers analyzed samples obtained from 112 patients with OSCC admitted to Guangdong Provincial Stomatological Hospital from March 2016 to March 2019. In OSCC tissues, the upregulation of ELF3-AS1 and glucose transporter 1 (GLUT1) was noted; these two factors were positively correlated. The expression of GLUT1 and glucose uptake was upregulated by ELF3-AS1 overexpression and was downregulated by ELF3-AS1 siRNA silencing in OSCC cells. Findings revealed that the proliferation of OSCC cells was promoted by ELF3-AS1 by reprogramming glucose metabolism.

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