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Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages

Cytokine Dec 19, 2021

de Brito RJVC, do Carmo RF, Silva BMS, et al. - In this study, liver tissues of patients with chronic hepatitis C were examined for the presence and quantity of IL-22, IL-22R1, and IL-22BP–producing cells.

  • Findings suggest a possible involvement of IL-22, IL-22R1 and IL-22BP in the mechanisms of liver fibrosis in patients with chronic hepatitis C.

  • More IL-22 expression was detected in liver biopsies at stage F1 to F3 vs F0 or F4.

  • With increase in fibrosis, there was a decrease in the number of cells expressing IL-22R1.

  • An increase in Il-22BP staining was observed in more advanced stages of fibrosis.

  • Possibly IL-22 pathway is involved in the pathophysiology of liver fibrosis.

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