Lu YW, et al. - Researchers explored the links between baseline low-density lipoprotein (LDL) concentrations and clinical outcomes in patients with acute myocardial infarction (AMI). A total of 409 patients were enrolled in the analysis and stratified by different nutritional status. The investigators used the Nutritional Risk Index (NRI) to estimate the risk of malnutrition. They noted increased incidences of in-hospital mortality, cardiogenic shock, decompensated heart failure, renal failure, and sepsis in patients in the lowest NRI tertile. Among patients with AMI, lipid paradox was noted in the high-risk of malnutrition population. In addition, the researchers continued to recommend aggressive lipid-lowering therapy for patients with AMI and fair nutritional status. The authors suggested that the improvement of nutritional status might be more advantageous than strict LDL control when treating patients at high risk of malnutrition.