Lifestyle factors and Parkinson disease risk: Korean nationwide cohort study with repeated health screening data
Neurology Feb 10, 2022
Findings demonstrate a relationship between lifestyle factors and Parkinson disease (PD) development.
In this nationwide population-based cohort study of Koreans who underwent health screening ≥3 times between 2002 and 2015 and followed up until December 31, 2015, researchers assessed the association of repeatedly measured lifestyle factors with PD risk.
Development of PD in 2,665 patients was revealed by the 14-year follow-up.
Only in males, there was a dose–response inverse association between smoking and PD (ex-smoker, odds ratio [OR] 0.782; current smoker, OR 0.556).
In both genders, alcohol intake and regular physical activity were found to be associated with decreased PD development.
However, alcohol intake in males (≤3 per week, OR 0.717; ≥4 per week, OR 0.745) and physical activity in females (moderate, OR 0.792; vigorous, OR 0.830) showed more consistent links with PD development than those of the other gender.
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