Drake I, et al. - In this prospective study using two Swedish cohorts— the Malmö Diet and Cancer Study (N=25,604) and the Malmö Preventive Project (N=16,216)—researchers assessed the magnitude of the link between a favorable lifestyle (based on non-smoking, normal-weight, absence of excessive drinking, regular physical activity, and healthy diet) and cancer incidence and mortality risk by using Cox regression stratified by family history of cancer (all types). A 22% and 40% lower risk of cancer incidence and mortality, respectively, was observed in relation to a favorable lifestyle vs an unfavorable lifestyle. Family history did not significantly modify these links, but subjects with ≥ 2 affected first-degree relatives exhibited a null link between lifestyle and cancer incidence. Overall, attenuated cancer incidence and mortality risk in the general population may be achieved by improving adherence to cancer prevention recommendations.