Nijenhuis-Rosien L, et al. - Researchers conducted this randomized, quadruple-blind, sham-controlled trial to assess the effectiveness and safety of the treatment of onychomycosis with local laser therapy. For this investigation, patients with diabetes mellitus microbiological confirmation at risk of developing diabetic foot ulcers (Sims classification score 1, 2) and a clinical suspicion on onychomycosis were randomized to either 4 sessions neodymium-doped yttrium aluminium garnet (Nd-YAG) 1064 nm laser or sham therapy. The most detected pathogen was Trichophyton rubrum. No difference was found in the primary outcome between laser and sham treatment. The findings proposed that treatment with Nd-YAG 1064 nm laser is secure, with the exception of a subungual haematoma in the fifth toenail that occurs 2 weeks after laser therapy. There is currently no evidence of any effect of onychomycosis laser treatment in patients with diabetes at increased risk of foot ulcer, at least not within one year of treatment.