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Lactated Ringer's solution vs normal saline in pediatric living‐donor liver transplantation: A matched retrospective cohort study

Paediatric Anaesthesia Mar 31, 2021

Dai WB, Chen LK, Qi SY, et al. - Among pediatric living‐donor liver transplantation patients, researchers conducted this single‐center, retrospective trial study for comparing the impact lactated Ringer's solution vs normal saline for intraoperative volume replacement has on clinical outcomes. Between January 2010 and August 2016, 333 children who received either lactated Ringer's solution or normal saline during living‐donor liver transplantation were analyzed. Lactated Ringer's solution administration was linked to a higher 90‐day mortality rate than normal saline (11.5% vs 0.0%) for intraoperative fluid management in pediatric living‐donor liver transplantation patients. This discovery has significant implications for crystalloid selection in pediatric living‐donor liver transplantation. Additional randomized clinical trials with larger cohorts are required to confirm this finding.

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