Li Y, Su Z, Wei B, et al. - Researchers systematically assessed the expression as well as clinical values of keratin 7 (KRT7; a member of the keratin gene family that is involved in the regulation of cell growth, migration and apoptosis in many malignancies) in pancreatic adenocarcinoma (PAAD). They found elevated mRNA and protein expression of KRT7 was exhibited by PAAD tissues vs normal tissues. A close relationship of high KRT7 expression with tumor grade, TP53 mutations and poor prognosis in PAAD patients, was found. In Cox regression analysis, overexpressed KRT7 was revealed as an essential as well as independent risk factor for poor overall survival and disease-free survival in PAAD. A significant link of KRT7 expression with immune infiltration of tumor immune cells and immunomodulators, was identified. The likely involvement of KRT7 in the regulation of the p53 pathway in PAAD, was suggested in functional enrichment analyses and Gene Set Enrichment Analysis. Overall, overexpressed KRT7 could serve not only as a promising prognostic but also a therapeutic target biomarker for PAAD by bioinformatics analysis.