Hahn RG, et al. - Given infusion with 0.9% saline represents a mainstay in the management of severe hyperglycemia, researchers studied the kinetics of the saline volume in this setting. Participants were 17 patients having hyperglycemia because of poorly controlled diabetes (mean age 51 years). The participants were administered an intravenous infusion of 1 L of 0.9% saline over 30 minutes on 31 occasions. Experts used mixed‐effects modeling software to fit a two‐volumekinetic model to serial data on the hemodilution and urinary excretion. Findings revealed rise in the excretion of 0.9% saline based on the degree of hyperglycemia. Glucose‐accelerated diuresis, and an intracellular uptake that happened at two‐thirds the urine flow rate, were shown to characterize the kinetics. These observations could assist to ascertain appropriate volumes as well as rates of infusion of crystalloids in hyperglycemia.