Okada A, et al. - The renoprotective ability of healthy people against kidney stone formation was investigated herein. Experts performed a quantitative and morphological observation of nephrectomized renal parenchyma tissues in order to clarify intratubular crystal kinetics and processing in human kidneys. Intratubular crystals in the renal parenchyma were noted to transmigrate to the interstitium regardless of the stone formation. The stone formers (SFs) vs non-stone formers (NSFs) with associated gene expression profiles could have reduced ability to eliminate renal parenchymal crystals, particularly those in the papilla region.