Liao G, Lee PMY, Zhao S, et al. - An increased benign prostatic hyperplasia (BPH) risk in relation to chronic oral bisphenol A (BPA) exposure was observed with a positive exposure–response association among Hong Kong Chinese, and the impact of BPA on BPH was amplified by alcohol intake.

• A total of 650 BPH cases and 650 controls were included from the same hospital in Hong Kong, and were examined with a validated cumulative BPA exposure index (CBPAI).

• A positive exposure–response link was evident between CBPAI and BPH risk.

• Frequent BPA exposure through oral consumption of foods heated in a plastic box/bag (odds ratio [OR] = 3.52), cooling water in a plastic bottle (OR = 2.65), or using a plastic cup to contain hot water (OR = 4.14), was significantly related to elevated BPH risk.

• An additive interaction between CBPAI and alcohol on BPH risk was indicated.

• To mitigate BPH risk, there should be minimizations of containing food or water/beverage in plastic containers and drinking alcohol.