Zeng Y, Li M, Chen S, et al. - Researchers conducted this retrospective study to further assess and confirm the potency of ¹⁸F-FDG PET/CT in diagnosing relapsing polychondritis (RP), a rare autoimmune inflammatory disease characterized by episodic inflammation of the cartilaginous tissue and proteoglycan-rich structures throughout the body, with airway involvement and monitoring response to steroid-based therapy. In total, 30 patients from a dedicated respiratory centre, diagnosed with RP in accordance with McAdam, Damiani or Levine criteria, were included. All participants in the study had baseline ¹⁸F-FDG PET/CT and 10 individuals had second scans after 2.5–15 months of steroid-based therapy. Data reported that 83.3% of patients were found to have FDG uptake in more than one cartilage in the initial scan. According to findings, ¹⁸F-FDG PET/CT helps to identify multiple involvements of cartilage in RP, but it seems neither a responsive nor precise tool in diagnosing RP with airway involvement. In addition, PET/CT has limited usefulness in identifying biopsy sites and monitoring corticosteroid therapy response.