Yang CW, et al. - Researchers conducted this comparative prospective cohort study to determine the roles of interferon-γ–induced protein-10 (IP-10)/CXCR3 axis in drug reaction with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). In order to evaluate the connection between IP-10, human herpes virus 6 (HHV-6) reactivation, and the development of long-term sequelae, plasma IP-10 levels were analyzed and univariate analyses were performed. In addition, they conducted immunohistochemistry staining utilizing skin specimens and flow cytometry to determine the expression of CXCR3 in peripheral blood mononuclear cells (PBMCs). Findings suggested an association of higher plasma IP-10 levels with the development of long-term sequelae in DRESS. In DRESS patients with HHV-6 reactivation, higher IP-10/CXCR3 expression in skin and more abundant CLA⁺CXCR3⁺CD4⁺ cells and CLA+CXCR3+CD8+ cells were noted. The IP-10/CXCR3 axis is linked to HHV-6 reactivation and long-term sequelae development in DRESS.