Al-Rohil RN, et al. - How lymphovascular invasion (LVI) identified through the D2–40 immunohistochemistry (IHC) compared with LVI detected via hematoxylin–eosin (H&E) staining with regard to the speculation of primary cutaneous Merkel cell carcinoma (MCC) metastasis was determined. D2–40 detected LVI displayed infiltrative growth pattern and non-brisk lymphoid infiltrate. A statistically notable variation was discovered between the frequency of detection of peritumoral LVI by H&E compared to D2–40 IHC. Larger MCCs, in which D2–40 IHC detected both intratumoral and peritumoral LVI, were compared to MCCs without. More frequent metastasis was also detected. D2–40 IHC detection of both intra- and peri-tumoral LVI was related to metastasis.