Koo CH, et al. - This study hypothesized that the intraoperative use of a high-dose remifentanil combined with a low-dose naloxone infusion reduces postoperative hyperalgesia compared with the use of remifentanil alone. Findings revealed that combined use of low-dose naloxone with high-dose remifentanil during the intraoperative period resulted in attenuation in postoperative hyperalgesia but not pain.