Komen H, et al. - Whether intraoperative methadone vs short-duration opioids would attenuate opioid consumption and pain in same-day ambulatory surgery, was investigated. Researchers also looked for an effective intraoperative induction dose of methadone for same-day ambulatory surgery. Overall 60 patients were included, who were randomized (2:1) to intraoperative single-dose intravenous methadone (initially 0.1 then 0.15 mg/kg ideal body weight) or conventional as-required dosing of short-duration opioids (eg, fentanyl, hydromorphone; controls), using a double-blind, dose-escalation protocol. Findings revealed attenuation in intraoperative and postoperative opioid needs and postoperative pain among patients who received a single intraoperative dose of methadone (0.15 mg/kg ideal body weight) vs conventional intermittent short-duration opioids. Also, similar side effects were seen between both groups of patients.