Kang RA, Jeong JS, Ko JS, et al. - Researchers examined if dexmedetomidine could reduce stress responses in cases undergoing endoscopic transnasal transseptal transsphenoidal surgery. Continuous infusion of 0.9% saline (n = 23) or dexmedetomidine (n = 23) was administered to 46 cases. Before surgery and at the end of drug infusion assessment of serum levels of epinephrine, norepinephrine, and glucose was done. Outcomes revealed reduction in norepinephrine release and rescue analgesic requirement in correlation with intraoperative dexmedetomidine administration. Hence, in patients undergoing transnasal transseptal transsphenoidal surgery, dexmedetomidine might have utility as an anesthetic adjuvant.