Sun GH, et al. - Herein, researchers sought to determine the impact of intraoperative administration of 4-factor prothrombin complex concentrate (4F-PCC) on blood product utilization, time to chest closure, intensive care unit (ICU) and hospital length of stay (LOS), thromboembolic complications, renal injury and mortality in left ventricular assist device (LVAD) patients on home anticoagulation therapy with warfarin, undergoing orthotopic heart transplantation (OHT). Findings demonstrated that replacing plasma with 4F-PCC to reverse preoperative warfarin anticoagulation during OHT was related to a shorter time to chest closure and less blood product utilization, with no reported increase in acute kidney injury, thromboembolic complications, or death.