Barker AK, et al. - An agent-based modeling approach was developed to evaluate the clinical effectiveness of interventions to reduce the incidence of hospital-onset Clostridium difficile infection in adult acute care hospitals. High yield strategies included identifying and managing the vast hospital reservoir of asymptomatic C. difficile by screening and daily cleaning with sporicidal disinfectant. Findings provided much needed data regarding which interventions to prioritize for optimal C. difficile control.