North L, Stadler M, Massey B, et al. - In this investigation involving 744 individuals, researchers analyzed the impact of adjuvant radiotherapy on survival in surgically-managed early-stage intermediate-grade mucoepidermoid and acinic cell carcinoma of the parotid. Between 2004 and 2015, the National Cancer Database was reviewed to identify individuals with intermediate-grade, early T-stage, node-negative parotid carcinoma who had parotidectomy ± radiotherapy. Data reported that 81% had mucoepidermoid carcinoma and 19% had acinic cell carcinoma. The authors discovered that adjuvant radiotherapy significantly and independently improves survival in those with postoperative positive margins in patients with early-stage intermediate-grade parotid carcinoma. Nevertheless, adjuvant treatment in those with negative margin resections does not tend to improve survival outcomes.