Marie RESM, Adel AZM, El- Fadeal NMA, et al. - Vitiligo patients exhibited higher serum levels of interleukin (IL)-38 than healthy controls (Hcs). IL-38 serum level was found to be linked with vitiligo severity and signs of activity.

• A total of 21 patients with vitiligo and 21 Hcs were included.

• A significantly higher serum level of IL-38 was detected in vitiligo patients vs Hcs (p < 0.001).

• In patients with signs of vitiligo activity, this level was significantly higher.

• In addition, this level showed positive correlation with Vitiligo Extent Score (p < 0.001), and negative correlations with age of patients (p = 0.001) and the age of disease onset (p = 0.022).