Riikonen R, Teräsjärvi J, Lauhkonen E, et al. - Findings showed that IL1RL1 (interleukin 1 receptor-like 1, encoded by the IL1RL1 gene) rs13048661/13431828 variation was related to post-bronchiolitis asthma outcomes at school age.

• IL1RL1 rs102082293, rs10204137 (rs4988955), rs13424006 and rs13431828 (rs13048661) variations were reported to be linked with asthma at school age, in the European birth cohorts.

• A Dutch multi-center study demonstrated association between IL1RL1 rs1921622 variation and severe bronchiolitis.

• Data from 141 children followed until 5–7 and for 125 children followed until 11–13 age years after bronchiolitis in infancy were analyzed to report the links of above-mentioned five IL1RL1 variations with asthma and lung function at school age post-hospitalization for bronchiolitis in infancy.

• A constant association of the variant IL1RL1 rs13048661/13431828 genotype with an elevated asthma risk was found, based on various definitions, at 5–7 and 11–13 years of ages.

• In analyses adjusted for current confounders and early-life environment-related factors, the finding was corroborated.

• Inclusion of maternal asthma and atopic dermatitis in infancy into the model led to loss of statistical significance.