Feng Q, Wong SH, Zheng J, et al. - Since processed meat and high sodium intake are common in the Western diet, researchers conducted both observational analysis with UK Biobank and genetic analysis with Mendelian randomization to investigate their independent impacts on the risk of colorectal cancer (CRC). The 24-hour urinary sodium and reported processed meat intake were fitted on incident CRC by a multivariable Cox proportional hazard model, which was adjusted for covariates like age, gender, family history, and so on. Four hundred fifteen thousand five hundred twenty-four eligible candidates from UK Biobank were involved. Two thousand six hundred sixty-three candidates were diagnosed with CRC during a median follow-up of 11.1 years. The consumption of processed meat had an independent effect on the risk of CRC, but the risk was unrelated to sodium level. Reducing processed meat consumption may be an effective strategy for CRC prevention, but sodium reduction is still recommended for other health benefits.