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Initial treatment of cancer patients with fluconazole-susceptible dose-dependent Candida glabrata fungemia: Better outcome with an echinocandin or polyene compared to an azole?

Antimicrobial Agents and Chemotherapy Aug 17, 2017

Le A, et al. – In cancer patients with fluconazole–susceptible dose–dependent Candida glabrata fungemia started on treatment (within 48 h after blood culture collection) with an echinocandin or liposomal amphotericin–B, the 28–day crude mortality rate was better (30%) in comparison to those treated with azole monotherapy (52%). After adjusting for confounders, azole monotherapy also seemed associated with worse 28–day survival.
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