de Abajo FJ, Rodríguez-Martín S, Barreira D, et al. - Correlation of influenza vaccination with risk of a first acute myocardial infarction (AMI) in the general population was examined by different epidemic periods.

• A population-based case–control study of patients aged 40–99 years was carried out in BIFAP (Base de datos para la investigación farmacoepidemiológica en atención primaria), over 2001–2015.

• Vaccinated individuals were those who received influenza vaccination at least 14 days prior to the index date within the same season.

• Included were 24,155 AMI cases and 120,775 matched controls.

• Shortly after vaccination, a reduction in the risk of AMI occurred and this protection persisted over time.

• Researchers retrieved similar findings during the pre-epidemic, epidemic and postepidemic periods.

• Overall influenza vaccine show a moderate protective effect against AMI in the general population, mostly in primary prevention,