Skorpen CG, et al. - A population-based study is performed to investigate the relationship between disease activity and medications with offspring birth weight, pre-eclampsia and preterm birth in systemic lupus erythematosus (SLE). The outcome revealed that the SLE has an increased odds for low birth weight and preterm birth, amplified by active disease. The also noticed that the odds for pre-eclampsia is elevated in active, but not an inactive disease. This calls for tight follow-up targeting inactive disease before and throughout pregnancy.