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Influence of CDK5 regulatory subunit-associated protein 1-like 1 expression on the survival of patients with non-metastatic nasopharyngeal carcinoma

Cancer Management and Research Jun 23, 2021

Li Z, et al. - Researchers investigated nasopharyngeal carcinoma (NPC) patients to ascertain if CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) expression could impact their survival. They retrospectively analyzed 140 non-metastatic NPC patients. Using immunohistochemistry, they identified the expression of CDKAL1. In Kaplan–Meier curve analysis, a better overall survival (OS) was shown in the CDKAL1-negative group, and 5-year OS rates for the CDKAL1-negative and -positive groups were revealed to be 89.7% and 70.2%, respectively. A tendency toward a better progression-free survival (PFS) rate was seen in the CDKAL1-negative group. An independent connection of CDKAL1 expression with both OS and PFS was observed in multivariate analysis. Overall, CDKAL1 expression was concluded to be an independent negative predictor of patient survival in non-metastatic NPC.

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