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Influence of BMI in nephrolithiasis in an Appalachian pediatric population: A single-center experience

Journal of Pediatric Urology May 31, 2018

Murphy MO, et al. - Authors probed if obese pediatric patients presenting with nephrolithiasis have a unique metabolic profile similar to reported findings in obese adults with nephrolithiasis. In an obese pediatric population, differences in types of stones and urinary metabolites were seen suggesting different metabolic profiles contributing to stone disease. A similar association between BMI and urine pH, urinary potassium, and citrate was seen. The primary presumption that obese pediatric patients would have a different urinary mineral profile as evidenced by lower levels of citrate and potassium and low urine pH was confirmed in the findings. Nonetheless, obese patients did not exhibit significantly elevated urinary sodium and uric acid when normalized to weight, as described in the adult population. This study failed to confirm the secondary hypothesis that stone composition would be associated with BMI status or stone recurrence.
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