Lechien JR, Carroll TL, Bobin F, et al. - Researchers conducted this prospective study for analyzing the influence of age and gender on the clinical presentation and therapeutic response of patients with laryngopharyngeal reflux (LPR). The sample consisted of 271 patients with a diagnosis of LPR confirmed by impedance-pH monitoring. Depending on the results of their impedance-pH results, patients were given 6 months of diet changes and a combination of pantoprazole and/or alginate. In total, 237 patients completed the evaluations (138 females). Age and gender may have an impact on the clinical presentation and evolution of symptoms and findings from pre- to post-treatment. Future therapeutic approaches could take age and gender differences into account to guide more effective personalized treatment plans for LPR patients.