Marzetti E, et al. - In this study involving 100 community-dwellers aged ≥ 70 years with physical frailty and sarcopenia (PF&S), researchers used a multivariate statistical approach to explore the link between a large panel of inflammatory biomolecules and PF&S in older adults, and explored gender-specific inflammatory patterns. They also included 100 non-sarcopenic, non-frail controls (non-PF&S) in this study. Higher levels of P-selectin, C-reactive protein (CRP), and interferon γ-induced protein 10 defined the inflammatory profile of people with PF&S. Higher levels of myeloperoxidase (MPO), interleukin (IL)-8, monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1-α, and platelet-derived growth factor (PDGF) BB characterized non-PF&S participants. A “core” inflammatory signature of PF&S was identified in this study by performing gender-specific partial least squares discriminant analysis. This signature consisted of higher levels of CRP and lower levels of MPO, IL8, MCP-1, and PDGF-BB, with peculiar patterns of links for men and women.