Hartwig FP, et al. - This study was conducted to examine the effect of inflammatory markers on schizophrenia risk in a 2-sample mendelian randomization (MR) design. The authors suggested a protective effect of C-reactive protein (CRP) and a risk-increasing effect of soluble interleukin-6 receptor (sIL-6R) (potentially mediated at least in part by CRP) on schizophrenia risk, under mendelian randomization assumptions. The possibility was found that such effects were a result of increased susceptibility to early life infection.