Mofors J, et al. – In this study, researchers investigated the influence of infections on primary Sjögren's syndrome (pSS) development. They analyzed patients with pSS in Sweden (n=945) and matched controls from the general population (n=9,048), and extracted data from the National Patient Register to identify infections occurring before pSS diagnosis during a mean observational time of 16.0 years. They noted an increased risk of developing pSS, most prominently SSA/SSB autoantibody-positive disease among patients who were infected, suggesting the contribution of microbial triggers of immunity in the pathogenetic process of pSS.