Corrêa ZM, et al. - Researchers aimed at defining 4 indication categories of fine-needle aspiration biopsies (FNABs) of solid intraocular tumors. Further, they sought to describe the differences among the patients, tumors, and results of biopsy in these 4 indication categories. Performing a retrospective descriptive analysis of 880 FNABs of a solid intraocular tumor of the posterior ocular segment performed at their ocular oncology practice, it was noted that in 372 cases (42.3%), FNABs were performed as a separate procedure, it was performed at plaque implantation in 279 cases (31.7%), postenucleation in 225 (25.6%), and postresection/prelaser in 4 (0.4%). Categorization of FNABs was as follows: diagnostic in 292 (33.2%), confirmatory in 121 (13.8%), investigational in 187 (21.3%), and prognostic in 280 (31.8%). Prior to the biopsy, a tumor of uncertain pathologic type was evident among all patients who underwent diagnostic FNAB, while a clinically diagnosed malignant intraocular neoplasm was reported in all patients who underwent confirmatory FNAB. In contrast, clinically, an unequivocal primary posterior uveal melanoma was evident in all patients who underwent a prognostic FNAB, while an unequivocal or probable malignant intraocular tumor of a specific type was noted in all patients who underwent an investigational biopsy. Findings thus suggest substantial differences among FNAB cases performed for different indications, hence it appears relevant to report results of FNAB or other biopsy methods according to the category (indication) of the biopsy.