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Increased incidence but lack of association between cardiovascular risk factors in adults born preterm

Hypertension Jan 31, 2020

Flahault A, Paquette K, Fernandes RO, et al. - Given an increased risk of early cardiovascular events and mortality is seen in relation to preterm birth, and cardiovascular risk factors cluster in the context of inflammation and oxidative stress in the general populace, so, researchers examined healthy young adults (n = 101; ages 18–29) born preterm (≤ 29 weeks of gestation) and full-term controls (n = 105), mainly (90%) white, to determine if this also happens in young adults born preterm. A higher risk of stage ≥ 1 hypertension, glucose intolerance, and airflow limitation was observed among individuals born preterm vs those born full-term. In those born full-term, but not in those born preterm, a strong link of hypertension with adiposity and with glucose intolerance was noted. There was no link of inflammation and oxidative stress with hypertension or glucose intolerance, but a link did exist with adiposity, in individuals born preterm. Experts found cardiovascular risk factors were not associated with each other in those born preterm, this indicates different pathophysiological pathways resulting in the development of cardiovascular risk after preterm birth. Considering screening for these abnormalities was, therefore, recommended regardless of other risk factors in this at-risk population.
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