Weber F, Junger H, Werner JM, et al. - Researchers analyzed samples of 18 anaplastic, 17 follicular, 27 papillary, and 4 medullary thyroid carcinomas as well as healthy tissue in order to determine the expression of immunoregulative receptor CD1d and lymphocyte infiltration, so that novel targets for an immunotherapeutic approach may be identified. In samples of thyroid tumors and in 19 specimens from normal thyroid tissue and in 10 samples of sarcoma, 7 malignant melanoma and 3 spindle-cell lung carcinoma, CD1d immunohistochemistry was performed. In this study, CD1d receptor expression on normal thyroid tissue was shown for the first time. Findings revealed that a significantly higher expression of CD1d, a receptor for natural killer T cells, was displayed by anaplastic thyroid carcinomas. These findings may provide a new approach to find out immunotherapeutic treatment options.