Liu C, et al. - Herein, the authors evaluated the expression and function changes of circulating CD4⁺CXCR5⁺FoxP3⁺ follicular regulatory T (TFR) cells in the active and stable remission of the patients with rheumatoid arthritis (RA). The role of TFR cells in the pathogenesis of RA was also clarified by them. A rise was found in the circulating TFR cells as RA patients developed to a stable state. It was determined that increased TFR cells could suppress autoimmunity of RA patients to stabilize their condition. Novel insight was gained into the pathogenesis of RA.