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Incidence, risk factors, and trends for postheart transplantation diabetes mellitus

The American Journal of Cardiology Dec 12, 2019

Munshi VN, et al. - Researchers investigated a cohort of patients who underwent first-time heart transplantation (HT) to study glycemic trends, the incidence of posttransplant diabetes mellitus (PTDM) incidence, and related risk factors in this retrospective study. They compared patient with and without pretransplant diabetes mellitus (DM) via univariate analyses. In order to define the link between PTDM and various risk factors, they used multivariate regression analyses. Of the 152 patients who had HT between 2010 and 2015, there was no pretransplant history of DM in 109. By the 1-year follow-up, PTDM incidence was estimated to be 38%. Increased odds of PTDM at 1 year were observed in relation to factors such as pretransplant BMI, insulin use during the final 24 hours of inpatient stay, mean inpatient glucose, and mean glucose in the final 24 hours prior to discharge. Significantly higher blood glucose values were detected in patients on insulin before discharge vs those who were not. Inpatient glucometrics may be informative of PTDM risk in HT patients, similar to liver and kidney patients. To account for risk heterogeneity and the requirement for differential management, constructing guidelines for this population was recommended.

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