Groeneveld Y, et al. - Via conducting a search of PubMed, Embase, Web of Science, and the COCHRANE Library for relevant studies published between January 1, 2000, and January 1, 2017, researchers examined the incidence of sight-threatening diabetic retinopathy in type 2 diabetes mellitus. Eligible studies included general populations of > 100 people with type 2 diabetes mellitus. There was a total of 17 studies included. In people with type 2 diabetes without or with baseline mild diabetic retinopathy, the average incidence rate of sight-threatening diabetic retinopathy was ~1 per 100 person-years and ~8 per 100 person-years. Investigators observed that the average number needed to screen for one case of sight-threatening diabetic retinopathy was 175 and 19 in persons without and with mild retinopathy at last screening. The incidence of severe sight-threatening retinopathy at the subsequent screening session was low in people with type 2 diabetes without retinopathy at last screening. Progression to sight-threatening diabetic retinopathy was nearly 10-fold higher in people with mild retinopathy. In this systematic review, lengthening of the screening interval of type 2 diabetes patients without retinopathy at last screening session was supported.