Gaddam S, Abboud Y, Oh J, et al. - An increase in the incidence of pancreatic cancer was evident among both genders (men and women) between 2000 and 2018.

• Using the SEER database, pancreatic cancer incidence rates per 100,000 population were collected (age-adjusted to the 2000 US population and adjusted for reporting delay) from 2000-2018, to perform an age- and gender-specific time trend analysis of pancreatic cancer incidence rates.

• There were 283,817 cases of pancreatic cancer (50% women) from 2000 to 2018, and significant increase in average annual percentage change of the total pancreatic cancer cases was evident in women (0.78%) and in men (0.90%) without a statistically significant between-group difference (0.12%).

• A greater relative increase in the incidence of pancreatic cancer was evident in women younger than aged 55 years, vs men, particularly in those aged 15 to 34 years.

• Although the reason for this relative rising trend among younger women is not clear, it could suggest a gender-based disproportional exposure to known or unknown risk factors.