Cordtz RL, et al. - Authors assessed the effect of the introduction of biological disease-modifying antirheumatic drugs (bDMARDs) and related rheumatoid arthritis (RA) management guidelines on the incidence of total hip (THR) and knee replacements (TKR) in Denmark. Compared with general population comparators (GPCs) in 1996, 3-fold and 14-fold higher rate of THR and TKR was noted respectively among patients with RA. In patients with RA, experts noted an association of introduction of bDMARDs with a decreasing incidence rate of TKR, whereas the incidence of THR had started to decrease before bDMARD introduction.