Noon SL, D’Annibale DA, Schwimmer MH, et al. - In this prospective, longitudinal cohort study, researchers determined the incidence of clinically diagnosed depression and anxiety in adolescents with nonalcoholic fatty liver disease (NAFLD). Between January 1, 2012 and July 1, 2018, this investigation was carried out in a Children's Hospital Pediatric Gastroenterology Clinic. Participants involved adolescents 12 to 17 years old at baseline with biopsy-confirmed NAFLD. In total, 160 adolescents with NAFLD were followed for a mean of 3.8 years. Data revealed that the incidence density of depression was 27 new cases per 1,000 person-years at risk, whereas the incidence density of anxiety was 18 new cases per 1,000 person-years at risk. NAFLD-affected adolescents had a high rate of clinically diagnosed depression and anxiety. In comparison to the available data in the general population, the rates were higher than predicted. Taking on this mental health issue would necessitate efforts on both the patient and system levels.