Hentilä E, Tiihonen M, Taipale H, et al. - Since antidepressant use is more common in people with Parkinson disease (PD), but it's unclear when this difference appears, researchers sought to examine the incidence of antidepressant use in 6-month time windows from 10 years before to 15 years after PD diagnosis in a nationwide cohort, and compare the incidence to a matched cohort without PD. This investigation involved 20,456 community dwellers with clinically verified PD diagnosed from 1996–2015 and 140,291 matched controls. Years before and after diagnosis, people with PD may experience symptoms that necessitate antidepressant medication. Among those with PD, 44.3% initiated antidepressants vs 25.0% of people without PD. The difference was largest 6 months prior to PD diagnosis. The difference emerged 7 years prior to diagnosis and stayed above the comparison group for most of the study period. Symptoms requiring antidepressant treatment may be clinical signs of possible PD, and they should prompt evaluation of clinical status in a person diagnosed with PD.