Ahn SG, et al. - Given that the benefit of transradial coronary interventions (TRIs) vs transfemoral coronary interventions (TFIs) might vary due to a given clinical condition, urgency of the procedure, and operator volume pattern, researchers looked for specific subgroups which would see a greater benefit from TRIs. For this purpose, they matched in-hospital outcomes of the TRI group (n = 22,993) to those of the TFI group (n = 15,581) in a cohort from the 2014 Korean Percutaneous Coronary Intervention Registry. They analyzed composite endpoints for all-cause death, nonfatal myocardial infarctions, or transfusions between groups and subgroups. Findings revealed favorable composite in-hospital outcomes with TRI vs TFI. Across subgroups, consistent benefits of TRI were noted, other than among patients with chronic kidney disease and those treated in low tertile PCI volume centers. Greater favorable TRI outcomes were seen in the elderly (≥75 years), patients with ST-elevation MI, those who underwent emergent PCI, and those treated in high tertile PCI volume hospitals.