Chuang KH, Lai HH, Chen Y, et al. - Given that surgery is the main treatment for esophageal cancer but is associated with a high risk of complications, and some surgical strategies have tested to eliminate complications, researchers conducted this meta-analysis to determine whether single-lumen endotracheal tube intubation with carbon dioxide (CO ₂ ) inflation is a beneficial option. They explored PubMed, Medline, and Scopus to identify studies on esophagectomy and CO ₂ inflation. The main outcomes were odds ratio of postoperative pulmonary complications and anastomosis leakage. Four case-control studies comprising 1,503 patients were analyzed in the meta-analysis. Per findings, improvement of pulmonary complications as well as shortening of hospitalization duration was conferred by single-lumen endotracheal tube intubation with CO ₂ inflation, however, it failed to exert a beneficial impact on anastomosis leakage.