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Improvement in the spatial distribution of pain, somatic symptoms, and depression following a weight-loss intervention

The Journal of Pain Sep 01, 2017

Schrepf A, et al. – Researchers planned this observational study to ascertain whether weight loss using a low–calorie diet improved pain, affect, and somatic symptoms commonly associated with chronic pain conditions, also report changes in inflammatory markers in serum before and after weight loss. They concluded that weight loss could improve diffuse pain and co–morbid symptoms commonly observed in chronic pain participants.

Methods
  • A total of 123 obese individuals undergoing a 12-16 week calorie restriction weight loss intervention participated in this study.
  • The researchers measured the spatial distribution of pain, symptom severity (e.g., fatigue, sleep difficulties), depression, and total fibromyalgia scale scores before and after weight loss.

Results
  • Following weight loss, pain (p =. 022), symptom severity (p = .004), depression (p < .001), and fibromyalgia scores (p= .004) improved.
  • Compared to women, men demonstrated greater improvement in somatic symptoms and fibromyalgia scores (both p < .01).
  • Compared to those who lost less than 10%, those who lost at least 10% of body weight demonstrated greater improvement.
  • Following the intervention, levels of the regulatory cytokine Interleukin-10 increased (p = .002).
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