Zhao J, et al. - Experts probed the role of IPO11 in bladder cancer (BCa) aggressiveness and elucidate the molecular mechanisms underlying its impacts in BCa. They noted that BCa cell invasiveness could be promoted by importin-11 overexpression, probably related to the deregulation of CDKN1A and THBS1 primarily through the activation of the proteoglycans in cancer pathway and the classical BCa pathway. As per the data, the progression of noninvasive BCa to invasive BCa could be blocked via targeting importin-11.