Wu XP, et al. - Among 76 prospectively recruited hypertrophic cardiomyopathy (HCM) patients (48 without and 28 with right ventricular [RV] hypertrophy), researchers evaluated RV function at rest and during exercise, as well as the link between impaired RV mechanics and exercise capacity. Thirty age- and sex-matched controls were also included. Using conventional echocardiography and 2-dimensional speckle-tracking imaging, assessments of RV function at rest and during semisupine bicycle exercise were carried out. Metabolic equivalents were used to measure exercise capacity. Findings revealed RV dysfunction and reduced contractile reserve among HCM patients. A correlation between exercise RV global longitudinal strain and exercise capacity was observed. Exercise RV global longitudinal strain was identified as an independent predictor of exercise intolerance. In addition, more reduced exercise capacity was observed in HCM patients with RV hypertrophy, which was indicative of more severe disease and poorer prognosis.