Impact of sex on clinical course and survival in the contemporary treatment era for hypertrophic cardiomyopathy
Journal of the American Heart Association Nov 09, 2019
Rowin EJ, et al. - Researchers examined large hypertrophic cardiomyopathy (HCM) cohort to determine disparities in clinical outcomes between men and women suffering from HCM. There were 2,123 consecutive patients, among those, a minority (38%) were women who received a diagnosis of HCM at older ages or referred for subspecialty assessment later than men. Women with HCM demonstrated no less favorable survival. In both genders, the efficacy of contemporary treatments including surgical myectomy to reverse heart failure and defibrillators to avert sudden death was evident, contributing to low mortality. However, under-recognition of women with HCM and their referral to centers later than men, often with more advanced heart failure, was reported, despite more frequent outflow obstruction. Earlier diagnosis and treatment should result from greater awareness of HCM in women, with implications for improved quality of life.
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