Huang Y, Chen S, Yang X, et al. - This study corroborates serum uric acid (sUA) as an independent risk factor for subclinical myocardial injury (SCeMI) post-adjustment for potential confounding variables, and existence of such an association in females only.

• From the National Health and Nutrition Examination Survey (NHANES) III, a total of 5880 adult individuals (57.9±13.0 years, 54.23% women) without known cardiovascular disease were analyzed.

• A non-linear association between sUA level and SCeMI was found post-adjustment for potential confounding variables.

• Each 100 unit elevation in sUA increased the risk of SCeMI by 15% when sUA was above the inflection point 266.5μmol/L.

• In females, each 100 unit rise in sUA elevated the risk of SCeMI by 71% when sUA>340.3 μmol/L but no significant correlation was identified in males.