Thongprayoon C, Cheungpasitporn W, Hansrivijit P, et al. - Given that changes in serum phosphate concentrations raised mortality in end-stage renal disease patients, and therefore, researchers investigated whether serum phosphate alterations during hospitalization are related to in-hospital mortality. They analyzed adult hospitalized patients with at least two serum phosphate measurements during their hospitalization. They classified in-hospital serum phosphate alterations into 5 groups: 0–0.6, 0.7–1.3, 1.4–2.0, 2.1–2.7, ≥2.8 mg/dL. Overall 28,149 patients were examined. In patients exhibiting serum phosphate changes of 0–0.6, 0.7–1.3, 1.4–2.0, 2.1–2.7, ≥2.8 mg/dL, the in-hospital mortality was estimated to be 1.5, 2.0, 3.1, 4.4, and 10.7%, respectively. Overall, findings demonstrated a progressive correlation of greater serum phosphate changes with raised in-hospital mortality.